Health Economics & Outcomes Research Literature Reviews

Literature Reviews

CTI’s team regularly conducts literature reviews which provide the basis for product development planning and subsequent clinical study design. Our literature reviews have been a significant component of regulatory submissions especially in the rare and orphan disease spheres.

We also conduct literature reviews suitable for submission of clinical and economic evidence to support global health technology assessment dossiers. Our team can perform literature reviews with a focus on the differing aspects of clinical and economic outcomes in order to support optimal market access.

Types of literature reviews often worked on by our team include:

Best Evidence Literature Reviews

CTI’s team undertakes best evidence literature reviews in order to collect the highest quality published clinical and economic evidence to support a healthcare technology without performing a systematic assessment or meta-analysis. We have developed deep and transferable knowledge of the published medical literature which we devote to each new project giving our clients the benefit of our past experiences.

Our team has years of research experience in developing and executing comprehensive best evidence literature searches to support:

  • health technology assessments
  • economic evaluations
  • clinical treatment guidelines
  • product diagnostics
  • adverse events

We understand the importance of performing timely and thorough best evidence scientific literature searches delivered in a transparent and acceptable method in order to ensure our reviews represent the latest evidence-based practice from the scientific literature.

We keep up to date on information retrieval methodology and technological advances ensuring our in-house processes incorporate the most applicable study design filters, reporting principles, and citation reference administration. Our internal peer review of literature search processes are designed to guarantee quality with complete documentation of all literature search tactics.

Amanda Coleman, MS
Assistant Research Scientist, HECOR
Amanda is a recent graduate of the Xavier University HECOR Masters program, which she completed while working at CTI. She has spent the last several years working on both internal and client specific HECOR projects.

Amanda Coleman

Systematic Literature Reviews and Meta Analyses

Systematic literature reviews are conducted for a wide variety of purposes that support development through post market surveillance of a pharmaceutical or medical device. 

Phase I-II:

  • Establish incidence and prevalence
  • Describe natural history
  • Determine current standards of care by geography
  • Develop appropriate clinical endpoints
  • Describe the unmet medical needs in rare and orphan diseases
  • Evaluate product utilization
  • Conduct cost-effectiveness and cost-utility analyses
  • Determine clinical value and build pricing models
  • Strategic planning to reach your product commercialization objectives
  • Work plan and protocol development
  • Data identification and subsequent extraction
  • Meta-analyses using the most up-to-date methodologies
  • Cost-effectiveness and cost-utility analyses
  • Clinical and economic outcomes
  • Peer-Reviewed medical communications

Later stages of development and commercialization:

  • Evaluate product utilization
  • Conduct cost-effectiveness and cost-utility analyses
  • Determine clinical value and build pricing models

CTIs team can provide:

  • Strategic planning to reach your product commercialization objectives
  • Work plan and protocol development
  • Data identification and subsequent extraction
  • Meta-analyses using the most up-to-date methodologies
  • Cost-effectiveness and cost-utility analyses
  • Clinical and economic outcomes
  • Peer-Reviewed medical communications
  • Product safety submissions

Epidemiology and Burden of Illness

The early stages of healthcare technology development often involve defining the patient population and impact of disease within a country, region, or specific payer. CTI’s team has expertise in appraising the published medical literature to provide essential information on diseases as measured by their financial cost, mortality, morbidity, and other indicators.

Our team can assemble information designed to demonstrate the epidemiology and country-specific burden of illness for a multitude of global payers. We can provide customized data solutions which accurately describe the clinical, economic and humanistic burden of diseases from multiple payer perspectives. We depend on recognized procedures and real-world evidence to generate information that is practical and useful in the global marketplace.

CTI’s team can provide our clients with geographically representative estimates of prevalence and incidence for diseases and their relevant treatments. Data derived from epidemiology and burden of illness studies can be important in defining the occurrence of clinical events which can subsequently be leveraged to identify market opportunities within important patient subgroups on a global and regional basis.

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